Randomized controlled trial

Form of scientific experiment

A randomized controlled trial (RCT) is a type of statistical experiment designed to evaluate the efficacy or safety of an intervention by minimizing bias through the random allocation of participants to one or more comparison groups. In this approach, at least one group receives the intervention or process under study (such as a drug, surgical procedure, medical device or diet), while the other groups receive an alternative treatment, a placebo, or standard care. RCTs are a fundamental methodology in modern clinical trials and have been widely considered one of the highest-quality sources of evidence in evidence-based medicine, due to their ability to reduce selection bias and the influence of confounding factors.

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