Ohio River

Major river in the Eastern United States

The Ohio River (Seneca: Ohi:yo') is a 981-mile-long (1,579 km) river in the United States. It begins in the Northeast and serves as the boundary between the Midwestern and Southern United States, flowing in a southwesterly direction from Pittsburgh, Pennsylvania, to its mouth on the Mississippi River at Cairo, Illinois. It is the third largest river by discharge volume in the United States and the largest tributary by volume of the Mississippi River.

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