Cocoliztli epidemics

16th century epidemics in New Spain

The Cocoliztli Epidemic or the Great Pestilence was an outbreak of a mysterious illness characterized by high fevers and bleeding which caused 5–15 million deaths in the North American territory of New Spain during the 16th century. The Aztec people called it cocoliztli, Nahuatl for pestilence. It ravaged the Mexican highlands in epidemic proportions, resulting in the demographic collapse of some Indigenous populations.

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